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ORX Awards and the Winners Are ... - September 2014 - Subscribe to Outpatient Surgery Magazine

Outpatient Surgery Magazine, providing current information on Surgical Services, Surgical Facility Administration, Outpatient Surgery News and Trends, OR Excellence and more.

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A new formula- tion of dantro- lene called Ryanodex (Eagle Pharmaceuticals) lets you get much more antidote into the patient much faster during a malignant hyperthermia crisis, but it's unknown whether a bigger, faster loading dose of dantrolene is clinically help- ful. Just 1 vial of Ryanodex provides a loading dose (2.5 mg/kg) of dantro- lene sodium for most patients. The company says Ryanodex can be pre- pared and administered in less than 1 minute, compared with 15 to 20 minutes for conventional dantrolene, which requires multiple 20 mg vials, each reconstituted in 60 mL of sterile water. Each vial of Ryanodex con- tains 250 mg of dantrolene sodium and requires reconstitution with only 5 mL of sterile water for injection. Once you have the first vial of Revonto or Dantrium reconstituted, you can begin administering the antidote, but for an adult patient, you'll need to keep mixing and recon- stituting — 8 or 10 or 12 more vials — to keep it flowing. But you'll pay for the convenience Ryanodex provides. As you'll see in the table below, Ryanodex costs more than twice as much as, and has a shorter shelf life than, Revonto (US WorldMeds) and Dantrium : Is the Convenience Of a New MH Antidote Worth the Cost? MALIGNANT HYPERTHERMIA MH DRILL In a malignant hyperthermia emergency, the sooner you start treatment after you make a diagnosis, the better. SURGEONS' Lounge THE O U T P AT I E N T S U R G E R Y M A G A Z I N E O N L I N E | S E P T E M B E R 2 0 1 4 3 2

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